About This CME Teaching Activity
This CME teaching activity is designed to provide a practical yet comprehensive review of soft tissue tumor pathology, including updates from the 2025 World Health Organization Classification. Integration of epidemiology, clinical information, and histology; a pattern-based approach to diagnosis; pearls and pitfalls; and the optimal application of ancillary diagnostic methods (especially immunohistochemistry) will be discussed.
Target Audience
This CME activity is primarily intended and designed to educate pathologists.
Educational Objectives
At the completion of this CME teaching activity, you should be able to:
- Apply a pattern-based approach to the differential diagnosis of soft tissue tumors.
- Discuss the differential diagnosis of cutaneous mesenchymal tumors.
- Describe the key features of pleomorphic soft tissue tumors.
- Recognize histologic and genetic subtypes of gastrointestinal stromal tumors.
- Apply a pattern-based diagnostic approach to vascular and nerve sheath tumors.
- Apply immunohistochemistry for the diagnosis of soft tissue tumors.
PROGRAM
| Introduction to Soft Tissue Pathology: The New 2026 WHO Classification, Grading, and a Pattern-Based Approach |
| Spindle Cell Tumors of Adults, Part I: Differential Diagnosis and Best Markers |
| Spindle Cell Tumors of Adults, Part II: Differential Diagnosis and Best Markers |
| Pleomorphic Sarcomas: It Is Easier Than You Think! |
| Round Cell Sarcomas: Histologic Clues and Ancillary Testing |
| Myxoid Tumors of Skin and Soft Tissue: From Benign to Malignant |
| Epithelioid Tumors: Diagnostic Challenges and How to Prevent Disaster |
| Vascular Tumors: Vasoformative and Not So Much |
| Nerve Sheath Tumors: Key Features and Problems |
| Gastrointestinal Mesenchymal Tumors: What Do We Need to Know? |
| Cutaneous Mesenchymal Tumors: What’s New? |
| Mesenchymal Tumors of the Head and Neck: Clues and Pitfalls |

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