​Theoretical and Clinical Geropharmacology​ (Advances in Pharmacology) (PDF)

by Mehmet Can Atayik, Ufuk Cakatay

​Theoretical and Clinical Geropharmacology​, explores the emerging field of senotherapeutics, which focuses on targeting cellular senescence to reduce age-related diseases and promote healthy aging. Chapters in this new release include Senotherapeutics: Milestones, innovations, and future prospects, Game Changer: Navigating between challenges and hopes in Geropharmacology, Next-Gen Senotherapeutics: AI/ML-driven strategies for aging and age-related disorders, Pharmacological frontiers in senescence: Transforming senescence with drug repurposing, Pharmacological potential of calorie restriction mimetics in mitigating brain aging, Isothiocyanates from cruciferous plants as geroprotectors, and much more.Other chapters cover Cellular parabiosis as a senotherapeutic approach, Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases, Mitochondria-associated membranes (MAMs) in age-related heart diseases, role of endoplasmic reticulum stress, Cellular senescence and senotherapeutics in cardiovascular diseases, Risk of senescence, polypharmacy, and their outcomes in elderly cardiovascular disease patients, Geropharmacology and gastrointestinal surgery, Oxygen-ozone adjunct therapy in aging and senescence-related disorders, and more.- Helps readers understand the nature of senotherapeutic agents and related cellular signaling cascades in health lifespan maintenance and age-associated pathologies- Includes discussions on how to pioneer new candidate senotherapeutic drugs that can be developed based on current scientific knowledge- Reveals how repurposed conventional drugs can be used in elderly patients- Proposes new drug-based therapeutic strategies suitable for this advanced age group