Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases (PDF)

by Igor Jose dos Santos Nascimento

Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases offers an in-depth overview of recent progress in drug discovery targeting some of the world’s most persistent and under-researched diseases. With a focus on medicinal chemistry and target-based drug design, this book explores critical pharmacological targets and innovative compounds aimed at combating neglected tropical diseases (NTDs) and related infections.Spread across ten chapters, the book examines the current state and future directions of therapeutic research for diseases such as leishmaniasis, Chagas disease, sleeping sickness, malaria, schistosomiasis, dengue, Zika virus, tuberculosis, and fascioliasis. Each chapter provides details about disease-specific targets, structural activity relationships (SAR), and developments in promising lead compounds over the past decade.
Key features:
-Focuses on pharmacological targets and medicinal chemistry strategies.
-Covers both parasitic and viral diseases with global health impact.
-Underlines emerging therapeutic approaches and SAR-guided design.
-Explains compound screening, optimization, and preclinical research.