About This CME Teaching Activity This Continuing Medical Education (CME) activity has been meticulously crafted to provide a comprehensive and up-to-date review of various topics frequently encountered by practicing surgical pathologists. The focus of the activity encompasses a range of areas such as gastrointestinal, hepatobiliary, genitourinary, gynecologic, breast, and soft tissue pathology. Notably, the goal is to equip pathologists with the knowledge and skills needed for accurate diagnoses, while also highlighting strategies to avoid common diagnostic pitfalls. The activity delves into the use of ancillary diagnostic techniques, including immunohistochemistry and molecular diagnostics, which significantly aid pathologists in reaching conclusive diagnoses.

Target Audience This CME teaching activity is primarily tailored to cater to practicing pathologists who are eager to enhance their understanding and proficiency in surgical pathology.

Educational Objectives Upon successful completion of this CME teaching activity, participants should be able to:

1. Identify Diagnostic Pitfalls: Discuss and recognize the most prevalent diagnostic pitfalls that pathologists may encounter while diagnosing well-differentiated lipomatous tumors.
2. Navigate Differential Diagnoses: Confidently navigate the differential diagnosis realm for tumors exhibiting myxoid, spindle cell, pleomorphic, and round cell features.
3. Integrate Clinical Data: Demonstrate the ability to integrate clinical history, laboratory data, and imaging findings to arrive at a consistent diagnosis, particularly when confronted with unexpected histologic attributes in liver biopsies.
4. Distinguish Hepatocellular Carcinoma: Differentiate between liver tumors that closely resemble hepatocellular carcinoma and utilize the appropriate immunostain panel for accurate identification.
5. Recognize Histologic Features: Identify key histologic features that facilitate the diagnosis of conditions like Wilson disease, hereditary hemochromatosis, and alpha-1 antitrypsin deficiency.
6. Understand Breast Cancer Subtypes: Summarize the morphologic and molecular characteristics of specialized histologic subtypes of triple-negative breast cancer, along with their implications for management.
7. Stay Updated on Biomarkers: Review the latest advancements in biomarker testing for breast cancer.
8. Solve Challenges in Biopsies: Address diagnostic challenges commonly encountered in breast core needle biopsies and formulate solutions for complex cases.
9. Decipher Colitis Patterns: Describe the various histologic patterns of colitis and their associated differential diagnoses.
10. Predict Prognosis in Colorectal Cancer: Recognize the critical factors that predict prognosis and guide therapeutic decision-making in colorectal cancer.
11. Classify Appendiceal Tumors: Classify appendiceal tumors using updated criteria to inform subsequent therapy and prognosis predictions.
12. Explore Prostate Pathology: Address contentious topics in prostate pathology, emphasizing grading and reporting parameters.
13. Diagnose Bladder Specimens: Examine common diagnostic challenges in bladder specimens and navigate their diagnosis.
14. Handle Kidney Tumors: Formulate a practical approach to dealing with common diagnostic challenges in kidney tumors.
15. Address Uterine and Ovarian Neoplasms: Discuss the most valuable histologic and immunohistochemical findings in diagnosing serious uterine and ovarian neoplasms, with an emphasis on HER2 testing.
16. Focus on Cervical Pathology: Analyze prevalent entities in cervical pathology as observed in post-menopausal patients.

This teaching activity stands as a valuable opportunity for practicing pathologists to enhance their skills and knowledge, thereby better serving patients and advancing the field of surgical pathology.