USCAP Don’t Go Down the Tubes Updates in the Diagnosis of Luminal Gastrointestinal Neoplasia 2025

Original release date: November 12, 2025
This intensive course features four gastrointestinal (GI) pathologists who will expertly guide you down the tubular GI tract, highlighting along the way important changes, updates and new considerations in the diagnosis and classification of neoplasia, as well as its precursors and important mimics. Categories of luminal neoplasms, including epithelial, neuroendocrine, and mesenchymal, will be reviewed and examined in a methodical manner, as they occur in the esophagus, stomach, small and large intestines, appendix, and anus.
Target Audience

Practicing academic and community pathologists, and pathologists-in-training

Learning Objectives
Upon completion of this educational activity, learners will be able to:

Describe, diagnose, and properly classify luminal neoplasia throughout the GI tract.
Discuss and evaluate precursor lesions and histologic criteria associated with progression.
Recognize essential syndromic associations and clinically relevant molecular abnormalities.
Distinguish entities in differential diagnosis and important mimics of luminal GI neoplasms.

Who Should Attend

Practicing surgical pathologists who routinely diagnose GI biopsies and resections
GI subspecialty pathologists seeking updates on evolving diagnostic criteria
Residents and fellows in pathology preparing for boards or subspecialty training
Academic clinicians and researchers interested in translational aspects of GI neoplasia
Oncology teams and multidisciplinary clinicians who rely on accurate pathology for patient management

What You’ll Learn
This USCAP short course emphasizes practical diagnostic challenges and updates in luminal GI pathology. Key highlights include:

Refinements in diagnostic criteria for adenomas, adenocarcinomas, and serrated lesions
Updates on molecular pathology and its role in classification and prognosis
Pitfalls and pearls in distinguishing reactive changes from neoplasia
Case-based discussions with expert faculty to sharpen interpretive skills
Integration of histology, immunohistochemistry, and molecular tools for accurate diagnosis

+ Topics:

Intestinal Polyps and Adenocarcinoma – Alexandros D. Polydorides, MD, PhD
Assorted Mesenchymal Cases in All Lineages – Elizabeth E. Montgomery, MD
Gastric Polyps – Gregory Y. Lauwers, MD
Esophageal Carcinoma and Precursors – Nicole C. Panarelli, MD
Appendiceal and Anal Neoplasia – Alexandros D. Polydorides, MD, PhD
GIST and Other Matters – Elizabeth E. Montgomery, MD
Gastric Metaplasia, Dysplasia, Carcinoma – Gregory Y. Lauwers, MD
Neuroendocrine Neoplasms – Nicole D. Panarelli, MD