Kentucky has more cancer diagnoses and cancer-related deaths than any other state in the nation, and most of these cases are concentrated in the fifty-four counties that constitute the Appalachian region of the commonwealth. These high rankings can be attributed to factors such as elevated smoking rates, unhealthy eating habits, lower levels of education, and limited access to health care. What is lost in the statistics is just how life-changing cancer can be — something that editors Nathan L. Vanderford, Lauren Hudson, and Chris Prichard have endeavored to address. The Cancer Crisis in Appalachia features essays written by a group of twenty high school and five undergraduate students, all of whom are residents of Kentucky’s Appalachian region and are participants in the University of Kentucky Markey Cancer Center’s Appalachian Career Training in Oncology (ACTION) program, which is funded by the National Cancer Institute’s Youth Enjoy Science Program. These authentic and candid student essays detail the effects of cancer diagnoses and deaths on individuals, families, friends, and communities, and proclaim these cases as more than nameless statistics. The authors shed light on personal cancer stories in hopes of inspiring readers to avoid cancer-risk behaviors, get involved with cancer-prevention initiatives, give generously, and uplift cancer patients and their loved ones.