Stem Cell Therapy for Autoimmune Disease by Richard K. Burt (2004-05-10) Hardcover – January 1, 1786

Stem Cell Therapy for Autoimmune Disease by Richard K. Burt (2004-05-10) Hardcover – January 1, 1786

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Stem Cell Therapy for Autoimmune Disease by Richard K. Burt (2004-05-10) Digital eBook – January 1, 1786

 
by Richard K. Burt  (Author) 
 
Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.
 

Product Details

  • File Size: 85310 KB
  • Print Length: 512 pages
  • Publisher: CRC Press; 1 edition (November 11, 2019)
  • Publication Date: November 11, 2019
  • Language: English

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