About the Book

Sample Sizes for Clinical Trials, Second Edition by Steven A. Julious is a practical guide that facilitates researchers in estimating the sample size for clinical trials. The book gives a comprehensive coverage of sample size calculations, which includes Normal, binary, ordinal, and survival outcome data. In addition to this, it covers superiority, equivalence, non-inferiority, bioequivalence, and precision objectives for both parallel group and crossover designs. It is equipped with detailed worked examples to illustrate how to do the calculations and present them in protocols. The book also highlights some of the pitfalls in calculation and the key steps leading to the final sample size calculation.

The second edition of this book has been revised, with some chapters being substantially revised, while four new chapters have been added on multiplicity, cluster trials, pilot studies, and single arm trials. The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and it could be used to teach a course on sample size calculations.

Features

• Covers all aspects of sample size calculations in clinical trials
• Highlights how trial objectives impact the study design
• Provides real-life clinical trial examples demonstrating the application of calculations
• Extended second edition with new chapters added

The importance of a sample size calculation when designing a clinical trial is emphasized in the book. With tables to assist in the calculations and an associated worked example, it enables readers to quickly find an appropriate sample size formula. This book is published by Chapman and Hall/CRC and is available in digital format with 420 pages.

Product Details

• Publisher ‏ : ‎ Chapman and Hall/CRC; 2nd edition (June 21, 2023)
• Language ‏ : ‎ English
• Format ‏ : ‎ eBook Digital
• Pages ‏ : ‎ 420
• ISBN-10 ‏ : ‎ 1138587893
• ISBN-13 ‏ : ‎ 978-1138587892