The human organism functions like a network of structured and interconnected systems, that influence and are influenced by the psychic dimension. Psychoneuroendocrinoimmunology (PNEI) is the study of the interaction between psychological processes and the nervous and immune systems of the human body. In this book PNEI paradigm presents itself in its full extension, according both to epistemology and physiology. Focused on the practical, preventive, and therapeutic implications of PNEI the Authors describe nervous, neuroendocrine, immune, psychic systems and their reciprocal influences, and show the modulation tools of the human network for preventive and therapeutic uses, such as nutrition, physical activity, psychotherapy, meditation and other behavioral and natural medicine techniques. Chapter by chapter, disease after disease, in critical dialogue with reductionist physiopathology and clinical hyperspecialisation, the book presents integrated care schemes, proposed on the basis of the available scientific evidence, for acute cardiovascular diseases, disturbances of the psyche-brain system (from depression to anxiety disturbances, schizophrenia, autism, neurodegeneration), immune disorders, eating and metabolism disorders, reproductive and sexual dysfunctions and cancer.