TIDES USA Oligonucleotide & Peptide Therapeutics 2025

A translational, end-to-end program covering discovery, delivery, CMC, analytics, manufacturing, and clinical development for oligonucleotide and peptide drugs. Sessions convert cutting-edge science into practical playbooks for moving candidates efficiently from idea to IND and through the clinic.
What You Will Learn

Platform selection & design: ASO/siRNA/miRNA/mRNA/saRNA vs. peptides/peptidomimetics—chemistries, stability, and manufacturability

Delivery strategies: LNPs, GALNAc, conjugates, depot and targeted systems; PK/PD and biodistribution considerations

CMC & analytics: impurity control, sequence confirmation, potency/stability assays, comparability, and QbD

Process development & scale-up: solid-phase/liquid-phase synthesis, hybrid approaches, purification and formulation

Regulatory & quality: IND/IMPD expectations, ICH alignment, control strategies, and lifecycle management

Nonclinical & clinical translation: models, safety/pharm-tox, biomarkers, dose selection, trial design

Operations: raw-material sourcing, supply chain resilience, technology transfer, and cost-of-goods levers

Data & digital: sequence optimization, structure prediction, in-silico off-target analysis, and AI/automation in analytics

Event Details

Format: Plenary talks, parallel technical tracks, case studies, panels, posters, and exhibits

Structure: Discovery/design → Delivery/PKPD → CMC/analytics → Manufacturing/scale-up → Clinical/regulatory → Commercialization

Takeaways: Checklists, templates, and benchmark metrics for immediate team adoption

Who Should AttendR&D scientists, CMC and QA/QC leaders, process/analytical chemists, formulation and delivery engineers, clinical and regulatory teams, manufacturing/operations managers, BD and strategy leaders, platform founders, and investors.
Why Attend

Replace trial-and-error with validated development pathways for RNA and peptide modalities

Anticipate regulatory and manufacturing pitfalls early to de-risk timelines and budgets

Build partnerships across discovery, CMC, and clinical teams to accelerate to proof-of-concept

 
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Schedule.pdf