This book presents a new, multi- and interdisciplinary approach to gastroesophageal reflux disease (GERD) and Barrett’s esophagus that reflects the latest advances in understanding of the disease. The role of each of the available diagnostic techniques, including endoscopy, histopathology, esophageal manometry, reflux monitoring, and EndoFLIP assessment, is carefully explained. The use of endoscopy for the purposes of mucosal ablation (radiofrequency ablation, cryoablation) and mucosal resection is described, and all aspects of anti-reflux surgery are covered, with detailed explanation of indications and techniques for standard fundoplication, endoscopic fundoplication, and surgical procedures using the LINX system and the EndoStim device. To assist the reader further, a novel interdisciplinary algorithm is presented for GERD diagnosis and treatment. In addition, the latest diagnostic and therapeutic approaches (including endoscopic and surgical resection and chemoradiation) are also presented for esophageal cancer and cancer palliation. A key feature of the book is its recognition of the contribution of different specialties in the management of GERD, and it will accordingly appeal to a wide range of practitioners.