Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management opens new horizons for exploring modern therapeutic entities and emerging targets for combating the deadly disease of cancer. The authors provide a review of cancer along with descriptions of its molecular level mechanisms and emphasize the role of promising new therapies, including herbal therapies that can be utilized for the treatment of metastatic diseases. The chapters look at specific approaches that have been researched and developed and that have almost reached the standardization stage. One of the approaches focuses on intracellular mechanisms, particularly proteins, and the pathway involving or being regulated by the proteins that limit the metastatic cellular growths. In particular phosphoprotein enriched astrocytes are being extensively tried. Also discussed is transerythretin protein, which has been significantly studied for its involvement in formation and transportation of proteins in metastatic diseases. Other receptors and approaches examined include CXCR4, autophagy-inhibiting drugs, phosphoprotein-enriched astrocytes, spatiotemporal genetic analysis, tyrosine kinase inhibitors, and more.