Dementia is on the rise around the world, and health organizations in Canada, the United States, and New Zealand are responding to the urgent need – voiced by communities and practitioners – for guidance on how best to address memory loss in Indigenous communities. This innovative volume responds to the call by bringing together, for the first time, studies and Indigenous teaching stories that address three key areas of concern: prevalence, causes, and public discourse; Indigenous perspectives on care and prevention; and culturally safe application of research to Elder care. Collectively, the contributors demonstrate that care must be grounded in collaborative research informed by Indigenous knowledge and worldviews.