Emergence of In Vitro 3D Systems to Model Human Malaria (PDF)

Through the desolate landscape of humanity, I’ve been flaunting my wild zeal of youth.

This book demonstrates the value and significance of the disease model in regards to malaria, this problem is globally recognized as a public health concern. This book describes the malaria’s biology in the liver and all in vitro platforms for the liver stage of malaria, including the principles, protocols, applications, and limitations of these platforms, as well as a description of how they are modeled and evaluated. The first chapter describes the fundamental principles of stem cells in the generation of hepatocytes during development and in adults. The following sections discuss recent and emerging research in the field of liver organoids and liver-on-a-chip that is dedicated to the modeling of malaria. The book discusses the current status of protocols and methods used to generate liver tissue in 3D and discuss their benefits and drawbacks. Toward the end, the book investigates the humanized mouse model of malaria in the liver using alternative artificial livers that have the potential to measure novel biomarkers. The recent development and troubleshooting of a combined liver chip technology with biosensors is described in order to assess the viability of hepatocytes and their functions. The book describes the potential of these 3D models to comprehend the biological complexity of the cellular and molecular mechanisms involved in the development of Plasmodium in the liver, to have toolboxes that can be used to investigate the way in which parasites are deployed in the 3D models, and to be practical in the development of new drugs. Ultimately, the book describes the future potential and difficulties associated with the use of liver organoids and live-stage malaria on-chip in the field of biology. This book is beneficial to scientists and researchers in the field of parasitology, cell biology, tissue engineering, and pharmacology.

Product information

Authors: Springer; 1st ed.

Speakers: English

eBook: digital version of 105 pages.

ISBN-11: 986016900

ISBN-13: 978-9819906901