This book discusses the clinical indications for chronic total occlusion (CTO) recanalization using percutaneous coronary intervention (PCI) and illustrates the recent academic findings on this constantly developing field of study. In addition to exploring the indications for revascularization and reading angiographies, the authors examine new strategies and techniques using innovative materials and equipment employing the antegrade, retrograde and their hybrid approaches, with a particular focus on the settings and management as well as the prevention of complications. They also describe the future potential of CTO PCI, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies.