•This handbook has been prepared with a practical outlook.•Different chapters on genetic causes, the impact of cervical factor, the effects of antiphospholipid antibodies, male factor and infections on recurrent pregnancy losses are presented.•A separate chapter on the endocrinological perspective in recurrent pregnancy losses has been included.•Investigative modalities proposed for the management of recurrent pregnancy losses such as ultrasound and hysteroscopy have also been dealt with in detail.•Proposed treatment options for this condition such as progesterone therapy and heparin treatment have been discussed in this book. •Newer management options which are picking up pace like preimplantation genetic diagnosis (PGD) and immunotherapy have been separately dealt with.•The option of assisted conception techniques to help couples has also found mention in a separate chapter.•Special chapters on setting up of an exclusive RPL clinic and tender loving care (TLC) are included as the emotional health of the sorrowing couple is equally important.•The chapters have been authored by leading clinicians and academicians from the length and breadth of the country.