COMPENDIUM OF IN VIVO MONITORING IN REAL-TIME MOLECULAR NEUROSCIENCE – VOLUME 2: MICRODIALYSIS AND SENSING OF NEURAL TISSUES (PDF)

By George S Wilson, Adrian C Michael Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques. These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest.
Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered.
Readership: Students and researchers in biochemistry, neurobiology, neuroanatomy, biomedical sciences and bioengineering.

Product Details

Publisher ‏ : ‎ World Scientific Publishing Company (August 23, 2017)
Language ‏ : ‎ English
Hardcover ‏ : ‎ 424 pages
ISBN-10 ‏ : ‎ 9813220538
ISBN-13 ‏ : ‎ 978-9813220539