Part of the Challenging Concepts in series, this book is a case-based guide to challenging clinical scenarios in neurology, covering 25 sub-speciality areas of the neurology curriculum. Each chapter is based around a potential real-life case, which is used as a platform to discuss the subject in a broader way and to explore the most up-to-date evidence regarding diagnosis and management. The book is written in a concise and easy to use format using “learning points”, “clinical tips” and “evidence-base” boxes as well as an “expert commentary” written by an internationally renowned expert in the field. The editors, expert commentators, and contributors are drawn from the National Hospital of Neurology and Neurosurgery (NHNN) at Queen Square, which has a unique position in the field of Neurology as a tertiary referral centre of world renown.