Wound healing is a complex cascade of events that led to reconstruct a damaged tissue with cellular and biological mechanisms. A Closer Look at Wound Infections and Healing first reviews the treatments mentioned in traditional Iranian medicine sources for various wounds. The various antibiotic alternative therapies that could be used against antimicrobial resistant bacteria in wound infections are reviewed in detail. The authors report on the complex role of estrogens and estrogenic derivatives in the wound healing process, with a focus on their therapeutic uses. The penultimate chapter explores the impact of photobiomodulation therapy on wound healing and the basic biochemical reactions involved. Photobiomodulation therapy involves the use of low-powered light emitting diodes, lasers or broadband light, mostly in the visible red and near infrared light spectrum. Postoperative surgical wound infection in the lumbar spine is unfortunately a common and potentially devastating complication. It is associated with increased morbidity and the need for further surgery. The authors discuss treatment of surgical wound infection centered on surgical debridement.