This book is a student reference guide book for the MD/PhD application process. It begins with an overview of the structure of a typical MD/PhD program as well as student outcomes and career choices of MD/PhD graduates. Next is an outline of the academic and extracurricular prerequisites as well as the basic components of the application itself. The authors then address the factors that MD/PhD students should consider when selecting schools to which to apply. Continuing to the main application, examples are provided of all the different essay types that MD/PhD applicants will encounter along with comments on how to address the deliberately vague and abstract prompts while tailoring the responses to the combined-degree program. Most uniquely, included is a very detailed explanation of the many types of interviews that applicants will encounter and how to prepare for them by integrating extensive personal experience and first-hand discussions with MD/PhD program leaders. Lastly, there will be a discussion on how to cope with the year-long timeline that constitutes this application process and provide guidance regarding properly responding to acceptances and waitlist offers.