Illustrative Case Studies in Haematology: Red Cell Riddles (PDF)

by Lucio Luzzatto, David R. Roper

Case reports that illustrate a logical stepwise approach to the understanding of common and rare haematological problems
Illustrative Case Studies in Haematology – Red Cell Riddles – is an educational book describing how the microscope, haematological findings, biochemical and molecular studies are used to reach a diagnosis. The book consists of 44 individual real-life case reports. Each case includes a brief clinical history, basic laboratory investigations, and initial impressions, leading to one or more possible diagnoses. Then, through more targeted investigations, the authors deliver a final diagnosis, which in most cases is at the molecular level.
For each case, a brief discussion is included, highlighting critical clinical and laboratory features, as well as recent progress in the area. Each individual case illustrates the close connection, in contemporary medicine, between clinical findings, haematological findings, and molecular analysis.
Illustrative Case Studies in Haematology includes:

Patients with sickle cell disease, ranging from nearly asymptomatic to life-threatening
Patients with different forms of thalassaemia
Kernicterus in a G6PD deficient female infant
Acquired alpha thalassaemia and myelodysplastic syndrome
Paroxysmal nocturnal haemoglobinuria in a G6PD deficient patient
The first case ever reported of homozygosity for an unstable haemoglobin
Cases with long-term follow-up spanning decades, demonstrating disease progression, complications and therapeutic outcomes

Illustrative Case Studies in Haematology includes patients from many different countries: therefore it may hold value to haematologists throughout the world, seeking to diagnose both common and rare disorders with clarity and confidence. The book is also highly appropriate for trainee haematologists, biomedical scientists and medical students.